Drug Information

Brentuximab vedotin

Brentuximab vedotin

Brand Names: U.S.

  • Adcetris™
Pharmacologic Category

  • Antineoplastic Agent, Monoclonal Antibody
When is it not safe to use this drug?

  • If you have an allergy to brentuximab vedotin or any other part of this drug.
  • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are pregnant or may be pregnant.
  • If you are breast-feeding.
What is this drug used for?

  • It is used to treat lymphoma.
How does this drug work?

  • Brentuximab harms cells causing their death.
How is this drug best taken?

  • It is given as a shot into a vein over a period of time.
What do I do if I miss a dose? (does not apply to patients in the hospital)

  • Call your doctor to find out what to do.
Are there any precautions when using this drug?

  • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
  • Talk with your doctor before using other aspirin, products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
  • Use birth control that you can trust to stop pregnancy while taking this drug and for up to 12 months after this drug.
What are some side effects of this drug?

  • Anemia, low white blood cell count, and low platelet count.
  • Feeling tired or weak.
  • Muscle or joint pain.
  • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
  • Headache.
  • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
  • Belly pain.
  • Loose stools.
  • Hard stools (constipation).
  • Cough.
  • Rash.
  • Fever.
  • Brain infection may rarely happen.
What do I need to watch for when using this drug?

  • Change in the health problem being treated. Is it better, worse, or about the same?
  • Have your blood work checked often. Talk with your doctor.
  • Follow up with the doctor.
When do I need to call my doctor?

  • If you think there was an overdose, call your local poison control center or ER right away.
  • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
  • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Change in thinking clearly and with logic.
  • Very bad dizziness or passing out.
  • Big change in balance.
  • Feeling very tired or weak.
  • Very bad headache.
  • Very upset stomach or throwing up.
  • Very bad belly pain.
  • Very loose stools.
  • Numbness or tingling in your hands or feet.
  • Any bruising or bleeding.
  • Very bad skin irritation.
  • Any rash.
  • Health problem is not better or you are feeling worse.
How do I store and/or throw out this drug?

  • This drug will be given to you in a hospital or doctor's office. You will not store it at home.
General drug facts

  • If you have a very bad allergy, wear an allergy ID at all times.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs out of the reach of children and pets.
  • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
  • In Canada, take any unused drugs to the pharmacy. Also, visit file://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
  • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
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